Xpovio: which tox species, and why?

“Rats were chosen as the rodent species and cynomolgus monkeys as the non-rodent species.”

“Based on available data, both species were determined to be pharmacologically relevant for toxicology studies.”

“Thirteen-week repeat-dose oral toxicity and toxicokinetic studies were conducted in the rat (0, 0.25, 1, or 4 mg/kg selinexor; 5 total doses given every 2-week period) and monkey (0, 0.1, 0.3, 1 mg/kg selinexor; 2 to 3 times/week) to support the NDA.”