Cardamyst: which tox species, and why?

“General toxicity studies were conducted with intranasal administration of etripamil for durations of up to 14 days in rats (once daily [QD]) and 6 months (once weekly) in monkeys.”

“Rats (rodent) and monkeys (nonrodent) were selected as appropriate animal species for toxicity testing because etripamil is rapidly metabolized to a primary inactive metabolite (MSP-2030) similarly in rats, monkeys, and humans.”

“No mortality, body weight changes, clinical chemistry, organ weights, macroscopic, or systemic microscopic findings were associated with the administration of etripamil up to 5.7 mg/kg/week.”