Livtencity: which tox species, and why?

“Pivotal repeat-dose toxicology evaluations for maribavir included good laboratory practice studies of up to 52 weeks duration in monkeys, 26 weeks duration in rats and 13 weeks duration in mice”

“Mice, rats and monkeys were chosen for single and repeat-dose toxicity studies because the main human metabolite of maribavir, VP 44469 was present in all of them and these species are common species for toxicity testing.”

“In the 52-week monkey study, 2 males at 400/300 mg/kg/day (two dose levels indicate dose adjustment during the study) and 1 male at 200 mg/kg/day were euthanized in extremis.”