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Atlas/Small molecules

Small molecules

Chemically synthesized new molecular entities: kinase inhibitors, receptor modulators, anti-infectives and more. 211 approved products. Click any cell to read the regulator's sentence.

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Which species?Rodent + dog or minipig121 of 211 precedents → How long?39 weeksmedian, range 1–78 wk → What did they skip?95 of 211 skipped carcinogenicityGenotox skipped 1/211 · repro 8/211 → How was the first dose set?Rarely public5 of 211 reviews say · how it's usually set →

Longest pivotal study, every precedent

Hover a dot · click to open · striped = derived from dosing schedule
041326395278 wk+9+42+2+93+9
ConductedConductedPartial / alternativePartial / payload / alternativeNot conductedNot conductedNot statedNot stated
211 of 211 shown
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Accruferferric maltol · Iron replacement →
Adqueydifamilast · PDE4 (topical) →
Agamreevamorolone · Glucocorticoid receptor (dissociative) →
Alyftrekvanzacaftor, tezacaftor and deutivacaftor · CFTR →
Anzupgodelgocitinib · Pan-JAK (topical) →
Aqneursalevacetylleucine · Neuronal metabolism (proposed) →
Artesunateartesunate · Plasmodium (antimalarial) →
Attrubyacoramidis · Transthyretin (stabiliser) →
Augtyrorepotrectinib · ROS1/TRK →
Avmapki Fakzynja Co-packavutometinib and defactinib · RAF/MEK clamp; FAK →
Ayvakitavapritinib · KIT/PDGFRA →
Azstarysserdexmethylphenidate and dexmethylphenidate · Dopamine/norepinephrine reuptake →
Balversaerdafitinib · FGFR1-4 →
Barhemsysamisulpride · Dopamine D2/D3 receptor →
Baxfendybaxdrostat · Aldosterone synthase (CYP11B2) →
Beqalzisonrotoclax · BCL-2 →
Blujepagepotidacin · Bacterial topoisomerases (gyrase/topo IV) →
Brenzavvybexagliflozin · SGLT2 →
Brexafemmeibrexafungerp · Fungal glucan synthase →
Brinsupribrensocatib · DPP1 (cathepsin C) →
Brukinsazanubrutinib · BTK →
Byfavoremimazolam · GABA-A receptor (benzodiazepine site) →
Bylvayodevixibat · IBAT →
Cabenuvacabotegravir and rilpivirine · HIV-1 integrase; NNRTI →
Camzyosmavacamten · Cardiac myosin →
Caplytalumateperone · 5-HT2A / D2 receptor →
Cardamystetripamil · L-type calcium channel →
Cibinqoabrocitinib · JAK1 →
Cobenfyxanomeline and trospium · Muscarinic M1/M4 agonist; peripheral antagonist →
Coselatrilaciclib · CDK4/6 →
Crenessitycrinecerfont · CRF1 receptor →
Cypsedocipepofol · GABA-A receptor →
Daybuetrofinetide · IGF-1 tripeptide analogue →
Dayvigolemborexant · Orexin OX1/OX2 receptors →
Defencathtaurolidine and heparin · Antimicrobial catheter lock →
Dojolvitriheptanoin · Anaplerotic energy substrate →
Duvyzatgivinostat · Histone deacetylase (class I/II) →
Egatentriclabendazole · Fasciola (tubulin) →
Ekterlysebetralstat · Plasma kallikrein →
Ensacoveensartinib · ALK →
Evrysdirisdiplam · SMN2 splicing →
Exblifepcefepime and enmetazobactam · PBPs; beta-lactamase (enmetazobactam) →
Exkivitymobocertinib · EGFR exon 20 insertion →
Exxuagepirone · 5-HT1A receptor →
Fabhaltaiptacopan · Complement factor B →
Fetrojacefiderocol · Penicillin-binding proteins →
Fexinidazolefexinidazole · Trypanosoma brucei →
Filsparisparsentan · Endothelin A / angiotensin II receptors →
Fotivdativozanib · VEGFR1-3 →
Foundayoorforglipron · GLP-1 receptor (non-peptide) →
Fruzaqlafruquintinib · VEGFR1-3 →
Gavretopralsetinib · RET →
Gemtesavibegron · β3-adrenergic receptor →
Gomeklimirdametinib · MEK1/2 →
Grafapextreosulfan · DNA alkylation →
Hernexeoszongertinib · HER2 (mutant) →
Hyrnuosevabertinib · HER2 (mutant) →
Ibsrelatenapanor · NHE3 →
Ibtrozitaletrectinib · ROS1 →
Idvynsodoravirine and islatravir · NNRTI; NRTTI →
Inluriyoimlunestrant · Estrogen receptor (SERD) →
Inpefasotagliflozin · SGLT1/SGLT2 →
Inqovidecitabine and cedazuridine · DNMT (decitabine); cytidine deaminase (cedazuridine) →
Inrebicfedratinib · JAK2 →
Iqirvoelafibranor · PPARα/δ →
Isturisaosilodrostat · 11β-hydroxylase (CYP11B1) →
Itovebiinavolisib · PI3Kα (mutant-selective) →
Jascaydnerandomilast · PDE4B →
Jaypircapirtobrutinib · BTK (non-covalent) →
Jesduvroqdaprodustat · HIF prolyl hydroxylase →
Jideytrozidesamtinib · ROS1 →
Joenjaleniolisib · PI3Kδ →
Journavxsuzetrigine · NaV1.8 →
Kerendiafinerenone · Mineralocorticoid receptor →
Klisyritirbanibulin · Tubulin / Src →
Komziftiziftomenib · Menin-KMT2A →
Koselugoselumetinib · MEK1/2 →
Krazatiadagrasib · KRAS G12C →
Kygevvidoxecitine and doxribtimine · Pyrimidine nucleoside replacement (TK2 deficiency) →
Lampitnifurtimox · Trypanosoma cruzi →
Lazcluzelazertinib · EGFR (mutant-selective) →
Leqselvideuruxolitinib · JAK1/JAK2 →
Lifyorlirelacorilant · Glucocorticoid receptor (antagonist) →
Litfuloritlecitinib · JAK3/TEC kinases →
Livdelziseladelpar · PPARδ →
Livmarlimaralixibat · IBAT (ASBT) →
Livtencitymaribavir · CMV UL97 protein kinase →
Lumakrassotorasib · KRAS G12C →
Lupkynisvoclosporin · Calcineurin →
Lybalviolanzapine and samidorphan · D2/5-HT2A; opioid receptors (samidorphan) →
Lynavoylinerixibat · IBAT →
Lynkuetelinzanetant · NK1/NK3 receptors →
Lytgobifutibatinib · FGFR1-4 (covalent) →
Mayzentsiponimod · S1P1/S1P5 receptor →
Mieboperfluorohexyloctane · Tear film evaporation barrier →
Miplyffaarimoclomol · Heat-shock response amplifier →
Modeysodordaviprone · DRD2 antagonist / ClpP agonist →
Myqorzoaficamten · Cardiac myosin →
Nereustradipitant · NK1 receptor →
Nexletolbempedoic acid · ATP citrate lyase →
Nextstellisdrospirenone and estetrol · Estrogen / progestin receptors →
Nourianzistradefylline · Adenosine A2A receptor →
Nubeqadarolutamide · Androgen receptor →
Nulibryfosdenopterin · cPMP replacement (MoCD type A) →
Nurtec ODTrimegepant · CGRP receptor →
Nuzolvencezoliflodacin · Bacterial topoisomerase II →
Ogsiveonirogacestat · Gamma secretase →
Ohtuvayreensifentrine · PDE3/PDE4 →
Ojemdatovorafenib · RAF (type II pan-RAF) →
Ojjaaramomelotinib · JAK1/JAK2/ACVR1 →
Olinvykoliceridine · μ-opioid receptor (G-protein biased) →
Omlontiomidenepag isopropyl · EP2 receptor →
Ongentysopicapone · COMT →
Orgovyxrelugolix · GnRH receptor →
Orladeyoberotralstat · Plasma kallikrein →
Orlynvahsulopenem etzadroxil and probenecid · Penicillin-binding proteins →
Orserduelacestrant · Estrogen receptor (SERD) →
Orzeyfuloveporexton · Orexin OX2 receptor agonist →
Oxbrytavoxelotor · HbS polymerisation →
Palsonifypaltusotine · Somatostatin receptor 2 →
Paxlovidnirmatrelvir and ritonavir · SARS-CoV-2 Mpro (3CL protease) →
Pemazyrepemigatinib · FGFR1-3 →
Piqrayalpelisib · PI3Kα →
Pizensylactitol · Osmotic laxative →
Ponvoryponesimod · S1P1 receptor →
Pretomanidpretomanid · Mycobacterial cell wall / respiration →
Pyrukyndmitapivat · Pyruvate kinase (activator) →
Qelbreeviloxazine · Norepinephrine reuptake →
Qinlockripretinib · KIT/PDGFRA →
Quliptaatogepant · CGRP receptor →
Quviviqdaridorexant · Orexin OX1/OX2 receptors →
Rapiblyklandiolol · β1-adrenergic receptor →
Rasonquedaraxonrasib · RAS(ON) multi-selective →
Recarbrioimipenem, cilastatin and relebactam · Beta-lactamase (relebactam) →
Relyvriosodium phenylbutyrate and taurursodiol · ER stress / mitochondrial (proposed) →
Retevmoselpercatinib · RET →
Revtorpykgedatolisib · PI3K/mTOR →
Revuforjrevumenib · Menin-KMT2A →
Reyvowlasmiditan · 5-HT1F receptor →
Rezdiffraresmetirom · Thyroid hormone receptor β →
Rezlidhiaolutasidenib · IDH1 (mutant) →
Rezurockbelumosudil · ROCK2 →
Rezzayorezafungin · Fungal glucan synthase →
Rhapsidoremibrutinib · BTK →
Rinvoqupadacitinib · JAK1 →
Romvimzavimseltinib · CSF1R →
Rozlytrekentrectinib · TRK/ROS1/ALK →
Rukobiafostemsavir · HIV-1 gp120 (attachment) →
Scemblixasciminib · BCR-ABL1 (STAMP, myristoyl pocket) →
Sephiencesepiapterin · Tetrahydrobiopterin precursor →
Simtriyocentanafadine · Triple monoamine reuptake →
Skyclarysomaveloxolone · Nrf2 activator →
Sofdrasofpironium · Muscarinic receptors (topical) →
Sohonospalovarotene · RARγ →
Sotyktudeucravacitinib · TYK2 →
Sunlencalenacapavir · HIV-1 capsid →
Sunosisolriamfetol · Dopamine/norepinephrine reuptake →
Tabrectacapmatinib · MET →
Tavneosavacopan · C5a receptor (C5aR1) →
Tazveriktazemetostat · EZH2 →
Tepmetkotepotinib · MET →
Trikaftaelexacaftor, tezacaftor and ivacaftor · CFTR →
Truqapcapivasertib · AKT1-3 →
Truseltiqinfigratinib · FGFR1-3 →
Tryptyracoltremon · TRPM8 agonist →
Tryvioaprocitentan · Endothelin A/B receptors →
Tukysatucatinib · HER2 →
Turaliopexidartinib · CSF1R →
Ubrelvyubrogepant · CGRP receptor →
Ukoniqumbralisib · PI3Kδ / CK1ε →
Utebzitebipenem pivoxil · Penicillin-binding proteins →
Vafseovadadustat · HIF prolyl hydroxylase →
Vanflytaquizartinib · FLT3 →
Vanrafiaatrasentan · Endothelin A receptor →
Vekluryremdesivir · SARS-CoV-2 RNA polymerase →
Velsipityetrasimod · S1P1/S1P4/S1P5 receptors →
Veozahfezolinetant · Neurokinin-3 receptor →
Veppanuvepdegestrant · Estrogen receptor (PROTAC degrader) →
Verquvovericiguat · Soluble guanylate cyclase →
Vivjoaoteseconazole · Fungal CYP51 →
Vizzaceclidine · Muscarinic agonist (miotic) →
Vonjopacritinib · JAK2/FLT3 →
Voqueznavonoprazan · H+/K+-ATPase (potassium-competitive) →
Voranigovorasidenib · IDH1/IDH2 →
Voydeyadanicopan · Complement factor D →
Vtamatapinarof · Aryl hydrocarbon receptor →
Vyndaqeltafamidis · Transthyretin (stabiliser) →
Wakixpitolisant · Histamine H3 receptor →
Wayrilzrilzabrutinib · BTK (reversible covalent) →
Weliregbelzutifan · HIF-2α →
Winleviclascoterone · Androgen receptor (topical) →
Xacdurosulbactam and durlobactam · PBPs; beta-lactamase (durlobactam) →
Xcopricenobamate · Sodium channel / GABA-A →
Xdemvylotilaner · Mite GABA-Cl channel →
Xeglyzeabametapir · Lice metalloproteinases →
Xenletalefamulin · Bacterial ribosome (50S PTC) →
Xocovaensitrelvir · SARS-CoV-2 3CL protease →
Xolremdimavorixafor · CXCR4 →
Xpovioselinexor · XPO1 →
Zavzpretzavegepant · CGRP receptor →
Zaynichcefepime and zidebactam · PBPs; beta-lactam enhancer (zidebactam) →
Zegfrovysunvozertinib · EGFR exon 20 insertion →
Zenbexusiberdomide · Cereblon (CELMoD) →
Zeposiaozanimod · S1P1/S1P5 receptor →
Zepzelcalurbinectedin · DNA minor groove (transcription) →
Zevteraceftobiprole medocaril · Penicillin-binding proteins →
Zokinvylonafarnib · Farnesyltransferase →
Ztalmyganaxolone · GABA-A receptor (positive modulator) →
Zulressobrexanolone · GABA-A receptor (positive modulator) →
Zurzuvaezuranolone · GABA-A receptor (positive modulator) →
Zycubocopper histidinate · Copper replacement (Menkes disease) →