Quviviq: which tox species, and why?

“repeat dose general toxicology studies in the mouse for up to 28 days, rat for up to 26 weeks, and dog for up to 39 weeks”

“Species selection was based on pharmacologically relevant binding to Orexin receptors in humans and in these non-clinical species with high selectivity and potency, metabolically relevant pathways in these species are similar to those in humans, as well as close plasma protein binding properties for some species only.”

“In Beagle dogs were administered 10, 30, or 100mg/kg/day Daridorexant for 39 consecutive weeks”