Anzupgo: which tox species, and why?

“repeat-dose toxicity studies in mice (dermal; 3 months), rats (oral; up to 6 months), dogs (oral; up to 9 months), and minipigs (dermal; up to 9 months)”

“Comparison of human, mouse and rat T cells demonstrated a comparable inhibitory effect across all species, supporting the in vivo species selection.”

“No treatment-related changes were observed in a 9-month dermal toxicity study in minipigs treated with delgocitinib ointment.”