Attruby: which tox species, and why?

“There were no histopathology findings consistent with kidney injury in chronic toxicology studies in two non-human species (Study 20141689, 26-week toxicity study in rats and Study 21141692, 39-week toxicity study in dogs)”

“Overall, there was no significant difference observed in PK profiles between animals and humans that would limit the interpretation of animal toxicology studies and the nonclinical species used were considered appropriate for the safety of acoramidis and its metabolites in human.”

“Repeat-dose toxicity studies were conducted in rats for up to 26 weeks with oral dose levels ranging from 50 to 1000 mg/kg/day.”