Tavneos: which tox species, and why?

“The Sponsor conducted oral toxicology studies up to 26 weeks in rats, 13 weeks in hamsters, and 44 weeks in monkeys.”

“The hamster and monkey were pharmacologically relevant species and could assess both potential on-target and off-target toxicity. However, the rat was not a pharmacologically relevant and could only assess potential off-target toxicity.”

“In the 13-week toxicology study in hamster, CCX168 was administered at doses of 0 (vehicle), 10, 30, 100 and 1000 (500 mg/kg BID) mg/kg/day.”