Ibsrela: which tox species, and why?

“Repeated dose toxicology studies of up to 6 months and 9 months were conducted in rats and dogs, respectively.”

“SLC9A3 (NHE3) expression was observed along the entire intestinal tract in the rat, dog, and human. NHE3 expression levels were similar across all three species throughout the intestine with a few segment specific differences noted.”

“In a 6-month toxicology study in rats, tenapanor was administered orally to SD rats at doses of 1, 3, and 10 mg/kg/day.”