Revuforj: which tox species, and why?

“Toxicology studies with up to 13 weeks of dosing were conducted in rats and dogs.”

“The use of the rat and dog as the rodent and non-rodent species for the pivotal repeat-dose toxicity studies of revumenib is supported by the in vitro metabolism and nonclinical PK data observed.”

“In the 13-week toxicology study in dogs, animals received revumenib doses of 12.5, 25, or 40 mg/kg/day.”