Rinvoq: which tox species, and why?

“General toxicology studies were conducted via the oral route of administration in rats and dogs.”

“The selection was based on the systemic exposure in rats and dogs which was much higher than in other investigated species. As discussed in the pharmacokinetics section, these species were shown to have similar elimination pathways and metabolic profiles of upadacitinib as in humans”

“Upadacitinib was administered to beagle dogs at oral doses of 0, 0.1, 0.5, and 1.5 mg/kg/day for up to 39 weeks.”