Vonjo: which tox species, and why?

“Mice and dogs were considered the most relevant nonclinical species for toxicological evaluations based on the similarity of their pacritinib metabolic profile to humans and the sufficient bioavailability observed in these nonclinical species.”

“Mice and dogs were considered the most relevant nonclinical species for toxicological evaluations based on the similarity of their pacritinib metabolic profile to humans and the sufficient bioavailability observed in these nonclinical species.”

“there were no cardiovascular effects attributed to the administration of pacritinib in the repeat-dose toxicity study in dogs dosed up to 14.2 mg/kg BID for 39 weeks.”