Wayrilz: which tox species, and why?

“the rat and dog were considered appropriate primary models for nonclinical safety studies, based on the similarity of oral bioavailability and metabolite profiles in these species to”

“This is because mouse, rat, dog, and rabbit BTK are nearly identical to the human version of the protein (approximately 99% homologous amino acid sequence), with no differences in the sites where rilzabrutinib binds.”

“Study 1281-16100: Nine-Month Oral GLP Toxicity Study of Rilzabrutinib in Beagle Dogs”