Rhapsido: which tox species, and why?

“As listed in the table below, general toxicity studies with remibrutinib were conducted in rats for up to 26 weeks and in dogs for up to 39 weeks.”

“The toxicological assessment was performed in pharmacologically relevant species (mouse, rat, rabbit and dog) that were sufficiently exposed to remibrutinib following the intended clinical route of administration (i.e. oral).”

“In a 39-week GLP oral repeat-dose toxicity study in beagle dogs, animals (4/sex/group) were administered doses of 0 (vehicle), 10, 50, and 300 mg/kg/day remibrutinib.”