Romvimza: which tox species, and why?

“Repeat-dose toxicology studies were conducted in rats (4-weeks, 13-weeks, and 26-weeks) and dogs (4-weeks, 13-weeks, and 39-weeks).”

“Rats, rabbits, dogs, and mice were selected as relevant species in the toxicology studies based on high protein homology (up to 96%) of the pharmacologic target of vimseltinib.”

“GLP repeat-dose toxicity studies were conducted with vimseltinib in rats and dogs up to 26 and 39 weeks of duration, respectively.”