Beqalzi: which tox species, and why?

“The GLP-compliant repeat-dose toxicology studies of up to 13 weeks of dosing were conducted in mice and dogs with animals dosed daily via oral gavage.”

“Mice and dogs were pharmacologically relevant species for toxicity evaluation, based on their high BCL2 sequence homology with humans, comparable metabolism profiles with humans in in vitro studies, and adequate bioavailability.”

“In the 13-week dog study, sonrotoclax was administered at doses of 10, 30, or 100 mg/kg/day.”