Rapiblyk: which tox species, and why?

“Reports of intravenous bolus and continuous infusion studies in rats and dogs up to 4-week duration were available.”

“Landiolol is metabolized in all species by hydrolysis of the ester moiety that produces M-1, which undergoes β-oxidation to the M-2 metabolite.”

“Note that the terms ONO-1101, Onact, and landiolol HCl (LAN) are interchangeably used in this review and represent the same active pharmaceutical.”