Zeposia: which tox species, and why?

“The main repeated dose toxicity studies have been conducted in Sprague Dawley rats and Cynomolgus monkeys with daily oral administration of ozanimod for up to 26 and 39 weeks, respectively.”

“Ozanimod was pharmacologically active in the nonclinical species (rat, monkey, rabbit, mouse) used to conduct the pivotal toxicology studies.”

“The main repeated dose toxicity studies have been conducted in Sprague Dawley rats and Cynomolgus monkeys with daily oral administration of ozanimod for up to 26 and 39 weeks, respectively.”