Brukinsa: which tox species, and why?

“Zanubrutinib was administered once daily to rats and dogs in studies up to 6 months in rats and 9 months in dogs.”

“Rats and dogs were chosen for the in vivo toxicity evaluation, as they are pharmacologically relevant species based on BTK sequence homology and functional assay.”

“In the 26-week study in rats, zanubrutinib was administered by oral gavage at 30, 100, 300, or 1000 mg/kg/day with a 4-week recovery period.”