Myqorzo: which tox species, and why?

“Repeat oral dose toxicology studies up to 26 weeks in rats and 39 weeks in dogs were conducted to support the chronic oral administration of aficamten intended for clinical use.”

“Both species are considered pharmacologically relevant given the high conservation of the cardiac myosin motor between species and based on in vitro and single-dose in vivo pharmacology studies.”

“Study Number/Title: Nonclin-0054/A 26-Week Study of CK-3773274 by Oral Gavage in Rats With a 2-Month Recovery Period”