Exblifep: which tox species, and why?

“general toxicology studies (28-day IV-dose studies in rats and dogs, a 28-day combination toxicology study with cefepime and enmetazobactam in rats, and a 13-week combination toxicology study with cefepime and enmetazobactam in dogs)”

“The metabolic profiles of enmetazobactam in rats, dogs, rabbits and humans were similar which supports the selection of these animal species as the primary toxicology species.”

“Enmetazobactam given alone to rats at doses of 125, 250 and 500 mg/kg/day and at doses of 60, 120 and 240 mg/kg/day to dogs was in general well tolerated.”