Qelbree: which tox species, and why?

“There are substantial species differences in the metabolism of viloxazine between the nonclinical species (rats and dogs) and humans.”

“It should be noted that despite the differences in the metabolic profiles, the exposure level to both the parent drug and its major human metabolite (glucuronidated-5-hydroxy-viloxazine) are adequately represented and characterized in rat”

“Viloxazine did not increase the incidence of tumors in rats treated for 2 years at oral doses of 30/22, 87/65/43, and 217/130/87 mg/kg/day.”