Xpovio: how was the first human dose set?

“Study treatment on Arm 1 during the dose escalation phase followed a standard 3+3 design with a starting dose of selinexor 3 mg/m2.”

“Rats exhibited toxicological sequalae due to hematopoietic/lymphoid hypoplasia and male/female reproductive organ effects. Female rats also exhibited higher liver weights and/or centrilobular hepatocellular hypertrophy and/or increased mitotic figures. Monkeys exhibited gastrointestinal effects and lymphoid/hematologic depletion.”