Aimovig: which tox species, and why?

“The pivotal, GLP-compliant toxicology studies were conducted in cynomolgus monkey, the only biologically relevant species”

“Erenumab has high affinity for the monkey and human CGRP-R, but not for rodent CGRP-R or closely related CGRP-R family members.”

“General toxicology studies were conducted exclusively in monkeys, due to a lack of pharmacological activity in other species.”