Remicade: which tox species, and why?

“A small number of chimpanzees, the only relevant species identified for safety testing, were given single or up to 5 once daily repeated doses of infliximab.”

“infliximab could neutralise human and chimpanzee TNFα with similar potency, while TNFα from a number of other species (rhesus cynomolgous, pigtail macaque, cotton-top tamarin, baboon, marmoset, pig, rabbit, rat and mouse) was not affected by infliximab.”

“In an attempt to mimic the clinical situation of TNFα inhibition, studies were conducted in mice using a monoclonal antibody against mouse TNFα (cV1q).”