Penpulimab: which tox species, and why?

“In in vitro studies, penpulimab bound to human and cynomolgus monkey PD-1 but did not bind rodent PD-1, supporting the use of cynomolgus monkeys as the single pharmacologically relevant species for toxicity assessment.”

“with EC50 values of 0.053 and 0.215 nM, respectively, but did not bind to mouse or rat PD-1, supporting the use of cynomolgus monkeys as a pharmacologically relevant species for toxicity assessment.”

“Given that pempulimab does not bind mouse PD-1, the Applicant investigated the in vivo antitumor activity of pempulimab in a human PD-1 knock-in genetically engineered mouse model (HuGEMM)”