Exdensur: which tox species, and why?

“The pharmacokinetics of depemokimab have been assessed in the Cynomolgus monkey, which is the only species relevant for the toxicity studies.”

“The difference in the affinity of depemokimab for human IL-5 (KD 39.1pM) and cynomolgus IL-5 (KD 23.9pM) was around two-fold less compared to mepolizumab that has equivalent affinities for human and cynomolgus IL-5 of 54.2 and 55.4pM respectively.”

“In an embryo-fetal development mouse study, CD-1 mice received SB264091, a rat anti-human IL-5 surrogate monoclonal antibody (lgG2b), which cross reacts with human and murine IL-5.”