Cablivi: which tox species, and why?

“The toxicology of caplacizumab was evaluated in single and repeat-dose toxicity studies in both rodent (guinea pig) and non-rodent species (Cynomolgus monkey).”

“Caplacizumab is cross-reactive to vWF in Cynomolgus monkey and guinea pig, but displays no pharmacological activity in rats, mice and dog.”

“This shows that caplacizumab is pharmacologically active in both species used for toxicity testing and that the animals were sufficiently exposed”