Monjuvi: which tox species, and why?

“The safety of tafasitamab was evaluated in GLP-compliant 8- and 13-week general toxicology studies in cynomolgus monkeys.”

“Binding of tafasitamab-FITC to human, cynomolgus monkey and rhesus monkey lymphocytes was comparable. Tafasitamab showed lower binding to rat and mouse, and no binding to dog and rabbit lymphocytes.”

“The studies were all conducted in cynomolgus monkeys (Macaca fascicularis), due to lack of tafasitamab antibody binding to lymphocytes in other common laboratory animal species.”