Crysvita: which tox species, and why?

“Hence, rabbits and cynomolgus monkeys were used in the in vivo nonclinical studies.”

“it was shown to bind with similar binding affinity (KD~10-11 M) to human, cynomolgus monkey and rabbit FGF23. KRN23 shows no binding to mouse, rat or dog FGF23.”

“A murine anti-FGF23 antibody at doses of 0, 3, 10 and 30 mg/kg was administered by SC injection twice a week for 2 weeks, or as a single dose, to male wild-type (WT) mice (C57BL/6J) and male hypophosphatemic (Hyp) mice (B6.Cg-PhexHyp/J).”