Aduhelm: which tox species, and why?

“The toxicology of aducanumab was adequately assessed in general toxicity studies in monkey and Tg2576 mouse.”

“Neither rat nor monkey is a particularly relevant species for general toxicity because of the lack of aggregated amyloid in rodent or non-aged monkey.”

“In Tg2576 mouse, ch12F6A was administered for 13 weeks (0, 10, 70, or 500 mg/kg) or 6 months (0, 10, 40, or 250 mg/kg) weekly by intravenous injection; in each study, a separate group received aducanumab (500 or 250 mg/kg, respectively) according to the same regimen.”