Niktimvo: which tox species, and why?

“The in vivo toxicology of axatilimab was assessed in the cynomolgus monkey, the only toxicology species in which axatilimab binds to CSF-1R and blocks CSF-1-mediated signaling of the receptor.”

“The in vivo toxicology of axatilimab was assessed in the cynomolgus monkey, the only toxicology species in which axatilimab binds to CSF-1R and blocks CSF-1-mediated signaling of the receptor.”

“In addition, an investigative mouse study was conducted, using a surrogate murine anti-CSF-1R antibody, to assess whether administration of an anti-CSF-1R antibody would influence the toxicity induced by a known hepatotoxin”