Erbitux: how long were the pivotal tox studies?

“The pivotal repeat-dose toxicity study is a 39 week study in Cynomolgus monkeys (study 070-087).”

“The initial doses and subsequent weekly doses were 12 and 7.5 mg/kg for the low dose group, 38 and 24 mg/kg for the intermediate dose group, and 120 and 75 5 mg/kg for the high dose group.”

“Toxicokinetics after repeated infusions of cetuximab to Cynomolgus monkeys, (0, 12, 38 and 120 mg/kg at week 1, subsequent weekly doses 0, 7.5, 24 and 75 mg/kg).”