Sylvant: how long were the pivotal tox studies?

“Repeat dose toxicology studies of 3-months or 6-months duration with extended recovery periods were conducted using weekly IV infusion administration of 9.6 or 46 mg/kg/dose siltuximab alone or in combination with IL-2 administration.”

“Repeat dose toxicology studies of 3-months or 6-months duration with extended recovery periods were conducted using weekly IV infusion administration of 9.6 or 46 mg/kg/dose siltuximab alone or in combination with IL-2 administration.”

“The repeat-dose toxicity of siltuximab was evaluated following once a week (q1w) IV 2-hour infusion of 9.2 and 46 mg/kg doses of siltuximab in 3- and 6-month studies (Study T-2002-007 and T-2003-010).”