Ilaris: how long were the pivotal tox studies?

“In the second study 26 weeks of treatment were followed by 6 weeks of recovery.”

“In two IV repeat-dose studies canakinumab was given twice a week at doses of 0, 10, 30 and 100 mg/kg. In the first study, a 4-week treatment period was followed by 8 weeks of recovery.”

“The local tolerance to canakinumab at the SC and IV injection sites were assessed in the course of the repeat-dose toxicity studies in marmoset.”