Yervoy: how long were the pivotal tox studies?

“In a 6-month toxicity study in cynomolgus monkeys, ipilimumab in a dose of 10 mg/kg with monthly intervals (4 times over these 6 months) was not associated with adverse drug-related toxicity”

“ipilimumab generally did not result in adverse toxicities in any other monkeys when administered IV at doses up to 30 mg/kg for 1 week, 10 mg/kg administered weekly for 1 month, 1 mg/kg weekly for 10 weeks, or 10 mg/kg monthly for up to 6 months.”

“Since ipilimumab is administered intravenously to humans, the IV route was evaluated in all monkey studies.”