Wayrilz: animal efficacy model or human cells?

“In a murine model for ITP, rilzabrutinib pretreated animals were stressed with an intraperitoneal injection of an anti-CD41 antibody to induce thrombocytopenia (DVR0288).”

“This is because mouse, rat, dog, and rabbit BTK are nearly identical to the human version of the protein (approximately 99% homologous amino acid sequence), with no differences in the sites where rilzabrutinib binds.”

“Hence, in the pivotal animal model, rilzabrutinib was not able to prevent full drop in platelets, was not able to reduce the drop velocity of platelets and was not able to significantly accelerate the recovery in platelet numbers.”