Fexinidazole: animal efficacy model or human cells?

“The activity of fexinidazole was measured in acute and chronic murine infection models of HAT.”

“Although the route of infection in mice is intraperitoneal, several aspects of the disease in T. brucei-infected animal models mimic human disease.”

“In the acute infection model, no relapse was reported in any study under the experimental conditions tested. However, in the chronic infection model, relapse was reported in some of the studies, which is probably due to the presence of the residual parasites in the brain.”