Zavzpret: how long were the pivotal tox studies?

“Intranasal toxicity studies of zavegepant were conducted in Sprague Dawley rat (4-, 13-, and 26-week) and cynomolgus monkey (4-, 13-, and 39-week).”

“Intranasal toxicity studies of zavegepant were conducted in Sprague Dawley rat (4-, 13-, and 26-week) and cynomolgus monkey (4-, 13-, and 39-week).”

“Because systemic exposure was low (“generally <2%”) following IN dosing, additional studies were conducted using subcutaneous administration to increase systemic exposure (4- and 13-week in rat; 4-week in monkey).”