Jesduvroq: which risks did reviewers probe?

“In monkeys, there were fewer organs of toxicity (only bone marrow [erythroid hypercellulartity], lung [alveolar hemorrhage], thymus [lymphoid atrophy], and stomach”

“Radioactivity concentrations in the uveal tract, pigmented skin, and meninges peak at 1h or 4h declining steadily afterwards until undetectable by Day 7. This finding suggests no irreversible binding to melanin-containing tissues.”

“Cause of death appeared related to hemorrhage, systemic thrombosis and/or necrosis and thrombosis of various organs including the heart, lung, kidney, and cecum. These findings are consistent with the drug’s primary pharmacology and secondary impact on hemodynamics.”