Sunlenca: which risks did reviewers probe?

“Using in vitro skin models, lenacapavir was not considered corrosive but was considered positive in two of three skin sensitization assays. However, in the in vivo assessment, lenacapavir was considered negative for sensitization potential.”

“No quantifiable or low levels of radioactivity were detected in brain and testes, respectively, suggesting that distribution of [14C]-lenacapavir-derived radioactivity was restricted by the blood to brain and blood-to-testes barriers.”

“The most common toxicity noted among all of the toxicology studies was injection site reactions.”