Tecvayli: which tox species, and why?

“The cynomolgus monkey was selected as the only pharmacologically relevant species for the nonclinical PK and toxicology assessments of teclistamab based on cross-species comparisons of sequence homology, relative target-binding affinities, and functional activity in cell-based assays.”

“The parental CD3 monoclonal antibody did not bind rodent CD3, and teclistamab is not expected to bind rabbit CD3 or BCMA due to low sequence similarity; thus, the cynomolgus monkey was determined to be a pharmacologically relevant species for toxicology studies.”

“The toxicity and toxicokinetics (TK) of teclistamab were evaluated in a 5-week repeat-dose toxicity study in cynomolgus monkeys.”