Elrexfio: which tox species, and why?

“Cynomolgus monkey was identified as the only relevant nonclinical toxicology species based on elranatamab binding affinities for BCMA and CD3.”

“Selection of cynomolgus as relevant species appears adequate, based on comparable binding affinity of elranatamab to cynomolgus and human BCMA and CD3, and a comparable frequency and phenotype of cynomolgus and human BCMA+ cells.”

“General toxicology studies were conducted in cynomolgus monkeys, a pharmacologically relevant species to assess the toxicity of elranatamab.”