Rybrevant: which tox species, and why?

“The cynomolgus monkey was selected as the only pharmacologically relevant species for the nonclinical pharmacokinetic (PK) and toxicology assessments of amivantamab based on a comparison of sequence homology, cross-species comparisons of relative target-binding affinities, and functional activity in cell-based assays.”

“Amivantamab bound to the ECD of human and cynomolgus monkey EGFR and MET with similar EC50 values (Table 3), but not to the ECD of rat EGFR or MET (data not included in review).”

“The cynomolgus monkey is considered the pharmacologically relevant species for the toxicology program of amivantamab (see Section 0, Safety Pharmacology).”