Imdelltra: which tox species, and why?

“The cynomolgus monkey was selected for toxicology testing given that tarlatamab similarly bound human and monkey CD3 and DLL3 but did not bind CD3 from other species.”

“However, the monkey may not be pharmacologically relevant considering DLL3 is expressed intracellularly in normal cells and tissues.”

“Following the proposal of the FDA, a murine surrogate molecule of tarlatamab, designated muS757, was developed to evaluate potential effects of a DLL3-targeting BiTE molecule on embryofetal development in mice.”