Blincyto: which tox species, and why?

“General toxicology studies included non-terminal repeat-dose studies of intravenous administration of blinatumomab in chimpanzees and repeat-dose studies of subcutaneous and intravenous administration of a murine surrogate in mice.”

“Blinatumomab bound to B and T lymphocytes from human and chimpanzee peripheral blood mononuclear cells (PBMC) but it did not bind to PBMC from the mouse, rat, beagle dog, squirrel monkey, African Green monkey, cynomolgus monkey, rhesus monkey, and baboon.”

“Because blinatumomab binds only to human and chimpanzee CD3 and CD19, the Applicant generated the murine surrogate muS103new for toxicology studies in mice and compared its activity to blinatumomab.”